|Wita et al, Adv Med Sci (2012)
||Microvolt T-wave Alternans Predicts Cardiac Events after Acute Myocardial Infarction in Patients Treated with Primary Percutaneous Coronary Intervention
"Our findings suggest that the MTWA test is a powerful predictor for a combined endpoint including not only mortality but also worsening of heart failure and defines a high-risk subgroup."
|Sredniawa et al, Kardiologia Polska (2012)
||Microvolt T-Wave Alternans and Other Noninvasive Predictors of Serious Arrhythmic Events in Patients with an Implanted Cardioverter-Defibrillator
||"The most important finding of our study was that abnormal MTWA was demonstrated to be an independent risk factor for [major arrhythmic cardiac events] following ICD implantation."
|Merchant et al., Heart Rhythm (2012)
||Clinical Utility of Microvolt T-wave Alternans Testing in Identifying Patients at High or Low Risk of Sudden Cardiac Death
||“In patients without ICDs, MTWA testing is a powerful predictor of SCD. Among patients with LVEF ≤ 35%, a negative MTWA test is associated with a low risk for SCD. Conversely, among patients with LVEF > 35%, a positive MTWA test identifies patients at significantly heightened SCD risk.”
|Merchant et al., Circ (2012)
||Role of Substrate and Triggers in the Genesis of Cardiac Alternans, From the Myocyte to the Whole Heart
||"In the present report we have attempted to present a novel framework for how an 'appropriate' substrate and an 'appropriate' trigger event may synergistically contribute to the mechanisms that generate cardiac alternans from the cellular to the whole-heart level, and we propose novel aspects of the use of [MTWA] to guide therapy."
|Shizuta et al., Clin Res Cardiol (2011)
||Prognostic Utility of T-Wave Alternans in a Real-World Population of Patients with Left Ventricular Dysfunction: The PREVENT-SCD Study
||"The event-free rate for severe ventricular tachyarrhythmic events in TWA-negative patients was excellent, 100% at 1 year, 98.6% at 2 years, and 97.0% at 3 years."
|Hohnloser et al., Heart Rhythm (2009)
||Evidence Regarding Clinical Use of Microvolt T-wave Alternans
||“This study found that MTWA testing using the spectral analytic method provides an accurate means of predicting [ventricular tachyarrhythmic events] in primary prevention patients without implanted ICDs; in particular, the event rate is very low among such patients with a negative MTWA test.”
|Costantini et al., JACC (2009)
||The ABCD (Alternans Before Cardioverter Defibrillator) Trial: Strategies Using T-Wave Alternans to Improve Efficiency of Sudden Cardiac Death Prevention
||“The ABCD study is the first trial to use MTWA to guide prophylactic ICD insertion. Risk stratification strategies using noninvasive MTWA versus invasive EPS are comparable at 1 year and complementary when applied in combination. Strategies employing MTWA, EPS, or both might identify subsets of patients least likely to benefit from ICD insertion.”
|Salerno-Uriarte et al., JACC (2007)
||Prognostic Value of T-Wave Alternans in Patients With Heart Failure Due to Nonischemic Cardiomyopathy: Results of the ALPHA Study
||“Among NYHA functional class II/III nonischemic cardiomyopathy patients, an abnormal TWA test is associated with a 4-fold higher risk of cardiac death and life-threatening arrhythmias.”
|Bloomfield et al., JACC (2006)
||Microvolt T-Wave Alternans and the Risk of Death or Sustained Ventricular Arrhythmias in Patients With Left Ventricular Dysfunction
||“Among patients with heart disease and LVEF ≤ 0.40, MTWA can identify not only a high-risk group, but also a low-risk group unlikely to benefit from ICD prophylaxis.”
|Chow et al., JACC (2006)
||Prognostic utility of Microvolt T-wave Alternans in Risk Stratification of Patients with Ischemic Cardiomyopathy
||“Microvolt T-wave alternans is a strong and independent predictor of all-cause and arrhythmic mortality in patients with ischemic cardiomyopathy.”
|Ikeda et al., JACC (2006)
||Predictive Value Of Microvolt T-Wave Alternans for Sudden Cardiac Death in Patients With Preserved Cardiac Function After Acute Myocardial Infarction: Results of a Collaborative Cohort Study
||“In patients with preserved cardiac function, the incidence of indeterminate results of microvolt TWA is low, and a positive test result is associated with arrhythmic events.”